Aaah yes! Ami is one of my favorite characters and it'd be awesome to get CR with her. It would be really good for Ishimaru to get to know someone else like him and realize that he doesn't have to go through his struggle alone. He unfortunately doesn't have many connections to the medical field but he does know Lucas and has a Blaziken that likes to lead him on wild goose chases around town. Perhaps a stop to the clinic would be warranted? That same Blaziken is also worried about Ishimaru missing out on the better things in life by studying too much, so he could mesh well with her Noctowl - or his Lucario, who believes in him wholeheartedly but desperately needs someone to talk to who ISN'T jumping over buildings or tearing up their room.

Side note - the word "genius" is a major berserk button for Ishimaru, but feel free to use it as often or infrequently as you like!